Publications - Articles

 

Year Title and Authors Journal  
2024
Reactions of in situ-generated difluorocarbene (:CF2) with aromatic/heteroaromatic alcohols, thiols, olefins, and alkynes under environmentally responsible conditions
 
Oftadeh, E.; Wong, M. J.; Yu, J.; Li, X.; Cao, Y.; and Lipshutz, B. H.
submitted  
2024

Environmentally friendly Miyaura Borylations allowing for green, 1-pot borylation/Suzuki-Miyaura couplings

Nelson, C. B.; L'Heureux, S. J.; Wong, M. J.; Kuhn, S. L.; Ghigletti, E.; and Lipshutz B. H.

submitted  
2024

Rapid aminations of functionalized aryl fluorosulfates in water

Iyer, K. S.; Dismuke Rogridguez, K. B.‡; Lammert, R. M.‡; Yirak, J. R.; Saunders, J. M.; Kavthe, R. D.; Aue, D. H.; and Lipshutz, B. H.

submitted  
2024
Dehydration in Water. Solid-Supported Lipases as Green Catalysts for Esterification
 
Thomas, R. M.; Lopez-Lemus, M. S.; Ganesh, K.; Obbard, D. B.; Sivashanmugam, K.; Sambasivam, G.; Yang, Y.; and Lipshutz, B. H.
Green Chem. accepted  
2024
Preparation of a key intermediate en route to the anti-HIV drug lenacapavir
 
Caravez, J. C.; Hu, Y.; Oftadeh, E.; Mamo, K. T.; and Lipshutz, B. H.
J. Org. Chem. 89, 3996-4000  Article
2024
Ligated Pd–catalyzed aminations of aryl/heteroaryl halides with aliphatic amines under sustainable aqueous micellar conditions
 
Iyer, K. S.‡; Kavthe, R. D.‡; Lammert Jr., R. M.; Yirak, J. R.; and Lipshutz, B. H.
JACS Au, 4, 680-689 Article
2024
Nanoparticles as heterogeneous catalysts for ppm Pd–catalyzed aminations in water
 
Iyer, K. S.; Kavthe, R. D.; Hu, Y.; and Lipshutz, B. H.
ACS Sus. Chem. Eng. 12, 1997-2008 Article
2024

Palladium-Catalyzed Aminations in Flow... on Water

Wong, M. J.; Oftadeh, E.; Saunders, J. M.; Wood, A. B.; and Lipshutz, B. H.

ACS Catal. 14, 1545-1552 Article
2023

Challenging cross couplings, in water, aided by in-situ iodination of (hetero)aromatic bromides

Thomas, R. M.; Obbard, D. B.; and Lipshutz, B. H. 

Chem. Sci. 14, 13503–13507 Article
2023
Use of Dipyridyldithiocarbonate (DPDTC) as an Environmentally Responsible Reagent Leading to Esters and Thioesters under Green Chemistry Conditions
 
Freiberg, K. M.; Ghiglietti, E.; Scurria, M.; and Lipshutz, B. H.
Green Chem. 25, 9941–9947

Article

Highlight

2023
Impact of Nonionic Surfactants on Reactions of IREDs. Applications to One-Pot Chemoenzymatic Sequences in Water
 
Li, X.; Hu, Y.; Bailey, J. D.; and Lipshutz, B. H.
Org. Lett. 26, 2778-2783 Article
2023
Pd-catalyzed carbonylations of aryl/heteroaryl halides in aqueous micellar media
 
Caravez, J. C.; Wong, M. J.‡, Kavthe, R. D.‡, Takale, B. S.; and Lipshutz, B. H.
ACS Catal. 13, 12383−12390 Article
2023
A streamlined, green, and sustainable synthesis of the anticancer agent erdafitinib
 
Singhania, V.; Nelson, C. B.; Reamey, M.; Morin, E.; Kavthe, R. D.; and Lipshutz, B. H.
Org. Lett. 25, 4308-4312 Article
2023
A Sustainable, Efficient, and Potentially Cost-effective Approach to the Antimalarial Drug Candidate MMV688533
 
Kavthe, R. D.; Iyer, K. S.; Caravez, J. C.; and Lipshutz, B. H.
Chem. Sci. 14, 6399-6407

Article

Commentary

2023

Facile, green, and functional group-tolerant reductions of carboxylic acids...in water

Iyer, K. S.; Nelson, C. B.; and Lipshutz, B. H.

Green Chem. 25, 2663-2671

Article

Highlight

Highlight

2023
A New Preparation of ppm Pd-Containing Nanoparticles as Catalysts for Chemistry in Water
 
Hu, Y.; Li, X.; Jin, G.; and Lipshutz, B. H.
ACS Catal. ​13, 3179-3186 Article
2023
Direct formation of amide/peptide bonds from carboxylic acids:  no traditional coupling reagents, 1-pot, and green
 

Freiberg, K. M.; Kavthe, R. D.; Thomas, R. M.; Fialho, D. M.; Dee, P.; Scurria, M.; and Lipshutz, B. H.

Chem. Sci. 14, 3462-3469

Article

Highlight

2023
Introducing Savie:  A Biodegradable Surfactant Enabling Chemo- and Bio-catalysis & Related Reactions in Recyclable Water
 
Kincaid, J. R. A.; Wong, M. J.; Akporji, N.; Gallou, F.; Fialho, D. M.; and Lipshutz, B. H. 
J. Am. Chem. Soc. 145, 4266-4278

Article

Highlight

2022

An Efficient & Sustainable Synthesis of the Antimalarial Drug Tafenoquine

Kavthe, R. D.; Kincaid, J. R. A.; Lipshutz, B. H.

ACS Sus. Chem. Eng. 10, 16896 Article
2022

A 1-pot synthesis of the SARS-CoV-2 Mpro inhibitor nirmatrelvir, the key ingredient in Paxlovid

Caravez, J. C., Iyer, K. S., Kavthe, R. D., Kincaid, J. R. A., and Lipshutz, B. H.

Org. Lett. 24, 9049 Article
2022

A Sustainable Synthesis of the SARS-CoV-2 Mpro Inhibitor Nirmatrelvir, the Active Ingredient in Paxlovid

Kincaid, J. R. A.; Caravez, J. C.; Iyer, K. S.; Kavthe, R. D.; Fleck, N.; Aue, D. H.; Lipshutz, B. H.

Comm. Chem. 5, 156

Article

Highlight

2022

ppm Pd-Containing Nanoparticles as Catalysts for Negishi Couplings…in Water

Hu, Y.; Wong, M.; Lipshutz, B. H.

Angew. Chem. Int. Ed. 61, e202209784 Article
2022

An environmentally responsible route to tezacaftor, a drug for treatment of cystic fibrosis prepared in water via ppm Au catalysis as entry to 2-substituted indoles

Fleck, N.; Thomas, R. M.; Müller, M.; Grimme, S.; Lipshutz, B. H.

Green Chem. 24, 6517 Article
2022

Impact of Aqueous Micellar Media on Biocatalytic Transformations Involving Transaminase (ATA); Applications to Chemoenzymatic Catalysis

Dussart-Gautheret, J.; Yu, J.; Ganesh, K.; Rajendra, G.; Gallou, F.; Lipshutz, B. H.

Green Chem. 24, 6172 Article
2022

Allylations of Aryl/Heteroaryl Ketones: Neat, Clean, and Green. Applications to Targets in the Pharma- and Nutraceutical Industries

Li, X.; Wood, A.; Lee, N.; Gallou, F.; Lipshutz, B. H.

Green Chem. 24, 4909 Article
2022

An Environmentally Responsible and Cost-effective Synthesis of the Antimalarial Drug Pyronaridine 

Kincaid, J. R. A.; Kavthe, R., D.; Caravez, J. C.; Takale, B. S.; Thakore, R. R.; and Lipshutz, B. H.

Org. Lett. 24, 3342 Article
2022

An Environmentally Responsible Synthesis of the Antitumor Agent Lapatinib (Tykerb)

Yu, J.; Iyer, K. S.; Lipshutz, B. H.

Green Chem. 24, 3640 Article
2022

Dehydration of primary amides to nitriles in water. Late-stage functionalization and 1-pot multistep chemoenzymatic processes under micellar catalysis conditions

Wood, A. B.; Kincaid, J. R. A.; Lipshutz, B. H.

Green Chem. 24, 2853 Article
2022

Lipase-catalyzed esterification in water enabled by nanomicelles. Applications to 1-pot multi-step sequences

Singhania, V.; Cortes-Clerget, M.;Dussart-Gautheret, J.; Akkachairin, B.; Yu, J.; Akporji, N; Gallou, G; Lipshutz, B. H.

Chem. Sci. 13, 1440

Article
2021

High Turnover Pd/C Catalyst for Nitro Group Reductions in Water. One-Pot Sequences and Syntheses of Pharmaceutical Intermediates

Li, X.; Thakore, R. R.; Takale, B. S.; Gallou, F.; Lipshutz, B. H.

Org. Lett. 23, 8114 Article
2021

Bisulfite addition compounds as educts for reductive aminations in water

Li, X.; Iyer, K.S.; Thakore, R. R.; Bailey, J. D.; Leahy, D. K.; Lipshutz, B. H.

Org. Lett. 23, 7205

Article
2021

Continuous Slurry Plug Flow Fe/ppm Pd Nanoparticle-Catalyzed Suzuki-Miyaura Couplings in Water Utilizing Novel Solids Handling Equipment

Wood, A. B., Plummer, S., Robinson, R. I., Smith, M., Chang, J., Gallou, F., Lipshutz, B. H.

Green Chem. 23, 7724

Article

Highlight

2021

Nanomicelle-enhanced, asymmetric ERED-catalyzed reductions of activated olefins. Applications to 1-pot chemo- and bio-catalysis sequences in water

Akporji, N., Singhania, V., Dussart-Gautheret, J., Gallou, F., Lipshutz, B. H.

Chem. Comm. 57, 11847 Article
2021 α-Arylation of (hetero)aryl ketones in aqueous surfactant media

Wood, A. B., Roa, D. E, Gallou, F., Lipshutz, B. H.

Green Chem. 23, 4858 Article
2021

Copper-Catalyzed Asymmetric Reductions of Aryl/Heteroaryl Ketones under Mild Aqueous Micellar Conditions

Fialho, D. M., Etemadi-Davan, E., Langner, O. C., Takale, B. S., Gadakh, A., Sambasivam, G., Lipshutz, B. H.

Org. Lett. 23, 3282 Article
2021

“TPG-lite”: a new, simplified “designer” surfactant for general use in synthesis under micellar catalysis conditions in recyclable water

Thakore, R. R., Takale, B. S., Hu, Y., Kostal, J., Gallou, F., Lipshutz, B. H.

Tetrahedron, 87, 132090 Article
2021

"Water-Sculpting of a Heterogeneous Nanoparticle Pre-catalyst for Mizoroki-Heck Couplings Under Aqueous Micellar Catalysis Conditions"

Pang, H., Hu, Y., Yu, J., Gallou, F., Lipshutz, B. H.

J. Am. Chem. Soc. 143, 3373 Article
2021

"Mild and robust Stille reactions in water using ppm levels of a new triphenylphosphine-based palladacycle"

Takale, B. S., Thakore, R. R., Casotti, G., Li, X., Gallou, F., Lipshutz, B. H. 

Angew. Chem. Int. Ed. 60, 4158

Hot Article

Article
2021

"Late-stage Pd-catalyzed cyanations of aryl/heteroaryl halides in aqueous micellar media"

Thakore, R. R., Takale, B. S., Singhania, V., Gallou, F., Lipshutz, B. H. 

ChemCatChem. 13, 212

Article
2020

"Safe, Scalable, Inexpensive, and Mild NickelCatalyzed Migitalike C–S CrossCouplings in Recyclable Water"

Yu, T., Pang, H., Cao, Y., Gallou, F., Lipshutz, B. H. 

Angew. Chem. Int. Ed. 59, 3708 Article
2020

"Environmentally responsible, safe, and chemoselective catalytic hydrogenation of olefins: ppm level Pd catalysis in recyclable water at room temperature"

Takale, B. S., Thakore, R. R., Gao, E. S., Gallou, F. Lipshutz, B. H.

Green Chem. 22, 6055

Hot Article 

Article
2020

"1-Pot synthesis of indoles and pyrazoles via Pd-catalyzed couplings/cyclizations enabled by aqueous micellar catalysis"

Landstrom, E., Akporji, N., Gabriel, C. M., Lee, N. R., Braga, F. C., Lipshutz, B. H. 

Org. Lett. 22, 6543 Article
2020

"Chemoselective Reductive Aminations in Aqueous Nanoreactors Using Parts per Million Level Pd/C Catalysis"

Thakore, R. R., Takale, B. S., Casotti, G., Gao, E. S., Jin, H. S., Lipshutz, B. H. 

Org. Lett. 22, 6324 Article
2020

"Sustainable Palladium-Catalyzed Tsuji−Trost Reactions Enabled by Aqueous Micellar Catalysis"

Lee, N. R., Moghadam, F. A., Braga, F. C., Lippincott, D. J., Zhu, B., Gallou, F., Lipshutz, B. H. 

Org. Lett., 22, 4949 Article
2020

"Nickel Nanoparticle-Catalyzed Mono- and Di-Reductions of gem-Dibromocyclopropanes Under Mild, Aqueous Micellar Conditions"

Wood, A. B., Cortes-Clerget, M., Kincaid, J. R. A., Akkachairin, B., Singhania, V., Gallou, F., Lipshutz, B. H. 

Angew. Chem. Int. Ed. 59, 17587 Article
2020

"Sustainable and Cost-Effective Suzuki–Miyaura Couplings toward the Key Biaryl Subunits of Arylex and Rinskor Active"

Takale, B. S., Thakore, R. R., Irvine, M. N., Schuitman, A., Li, X., Lipshutz, B. H.

Org. Lett. 12, 4823 Article
2020

"Continuous Flow Suzuki-Miyaura Couplings in Water Under Micellar Conditions in a CSTR Cascade Catalyzed by Fe/ppm Pd Nanoparticles"

Wood, A. B., Nadiwale, K. Y., Mo, Y., Jin. B., Pomberger, A., Schultz, V. L., Gallou, F., Jensen, K. F., Lipshutz, B. H.

Green Chem. 22, 3441  Article
2020

"N2Phos – an easily made, highly effective ligand designed for ppm level Pd-catalyzed Suzuki– Miyaura cross couplings in water"

Akporji, N., Thakore, R. R., Cortes-Clerget, M., Anderson, J., Landstrom, E., Aue, D. H., Gallou, F., Lipshutz, B. H. 

Chem. Sci. 11, 5205  Article
2019

"Surfactant Technology: With New Rules, Designing New Sequences Is Required!"

Lippincott, D., Landstrom, E., Cortes-Clerget, M., Lipshutz, B. H., Buescher, K., Schreiber, R., Durano, C., Parmentier, M., Ye, N., Shi, M., Yang, H., Andersson, M., Gallou, F.

Org. Process Res. Dev. 24, 841 Article
2019

"A Sustainable 1-pot, 3-step Synthesis of Boscalid using Part Per Million Level Pd Catalysis in Water"

Takale, B. S., Thakore, R. R., Mallarapu, R., Gallou, F., Lipshutz, B. H.

Org. Process Res. Dev. 24, 101 Article
2019

"An environmentally responsible 3-pot, 5-step synthesis of the antitumor agent sonidegib using ppm levels of Pd catalysis in water"

Takale, B. S., Thakore, R. R., Kong, F. Y., Lipshutz, B. H.

Green Chem. 21, 6258  Article
2019

"N,C-Disubstituted Biarylpalladacycles as Pre-catalysts for ppm Pd-catalyzed Cross Couplings in Water Under Mild Conditions"

Thakore, R. R., Takale, B. S., Gallou, F., Reilly, J., Lipshutz, B. H.

ACS Catal. 12, 11647 Article
2019

"Fe-catalyzed reductive couplings of terminal (hetero)aryl alkenes and alkyl halides under aqueous micellar conditions"

Pang, H., Wang, Y., Gallou, F., Lipshutz, B. H. 

J. Am. Chem. Soc. 141, 17117 Article
2019

"Discovery-Based SNAr Experiment in Water Using Micellar Catalysis"

Landstrom, E. B., Nichol, M., Lipshutz, B. H., Gainer, M. J.

J. Chem. Educ. 11, 2668 Article
2019

"Sustainable ppm Level Palladium-Catalyzed Aminations in Nanoreactors Under Mild, Aqueous Conditions"

Zhang, Y., Takale, B. S., Gallou, F., Reilly, J., Lipshutz, B. H. 

 

Chem. Sci. 10, 10556 Article
2019

"Selective Deprotection of the Diphenylmethylsilyl (DPMS) Hydroxyl Protecting Group Under Environmentally Responsible, Aqueous Conditions"

Akporji, N., Lieberman, J., Maser, M., Yoshimura, M., Boskovic, Z., Lipshutz, B. H.

Chem. Cat. Chem. 11, 5743 Article
2019

"Synergistic Effects of ppm Levels of Palladium on Natural Clinochlore: a New Reagent for Reductions of Nitroarenes"

Gholinejad, M., Oftadeh, E., Shojafar, M., Sansano, J. M., and Lipshutz, B. H. 

Chem. Sus. Chem. 12, 4240 Article
2019

"Atroposelective Total Synthesis of the Fourfold ortho-Substituted Naphthyltetrahydroisoquinoline Biaryl O,N-Dimethylhamatine"

Slack, E. D., Seupel, R., Aue, D. H., Bringmann, G., and Lipshutz, B. H.

Chem. Eur. J. 25, 14237 Article
2019 "A new, substituted palladacycle for ppm level Pd-catalyzed Suzuki-Miyaura cross couplings in water"

Takale, B. S., Thakore, R. R., Handa, S., Gallou, F., Reilly, J. and Lipshutz, B. H.

Chem. Sci. 10, 8825 Article
2019

"MC-1. A “designer” surfactant engineered for peptide synthesis in water at room temperature"

Cortes-Clerget, M., Spink, S. E., Gallagher, G. P., Chaisemartin, L., Filaire, E., Berthon, J-Y., and Lipshutz, B. H.

Green Chem. 21, 2610 Article
2019

Bridging the gap between transition metal- and bio-catalysis via aqueous micellar catalysis

Cortes-Clerget, M.; Akporji, N.; Zhou, J.; Gao, F.; Guo, P.; Parmentier, M.; Gallou, F.; Berthon, J-Y.; Lipshutz, B. H.

Nat. Comm. 10, 2169

Article

Behind the paper

Highlight

2019

Synthetic chemistry in water: applications to peptide synthesis and nitro-group reductions

Cortes-Clerget, M.; Lee, N. R.; Lipshutz, B. H.

Nat. Protoc. 14, 1108 Article
2019

Coolade. A Low-Foaming Surfactant for Organic Synthesis in Water

Lee, N. R.; Cortes-Clerget, M.; Wood, A.;  Lippincott, D. J.; Pang, H.; Moghadam, F.; Gallou, F.; Lipshutz, B.H.

ChemSusChem, 12, 3159 Article
2019

Sonogashira Couplings Catalyzed by Fe Nanoparticles Containing ppm Levels of Reusable Pd, under Mild Aqueous Micellar Conditions

Handa, S.; Bo, J.; Bora, P. P.; Wang, Y.; Zhang, X.; Gallou, F.; Reilly, J.; Lipshutz, B. H.

ACS Catal. 9, 3, 2423 Article
2019

ppm Pd-Catalyzed, Cu-free Sonogashira couplings in water using commercially available catalyst precursors

Bo, J.; Gallou, F.; Reilly, J.; Lipshutz, B. H.

Chem. Sci. 10, 3481.

Highlighted in ChemSci Pick of the Week

Article

Highlight

2018

Copper-Catalyzed Oxidative Cleavage of Electron-Rich Olefins in Water at Room Temperature

Lippincott, D. J.; Trejo-Soto, P. J.; Gallou, F.; Lipshutz, B. H.

Org. Lett., 20, 5094. Article
2018

Synthesis of Functionalized 1,3-Butadienes via Pd-Catalyzed Cross-Couplings of Substituted Allenic Esters in Water at Room Temperature

Lippincott, D. J.; Linstadt, R. T. H.; Maser, M. R.; Gallou, F.; Lipshutz, B. H.

Org. Lett.20, 4719.

Article
2018

EvanPhos. A New Ligand for ppm Pd-Catalyzed Suzuki-Miyaura Coupling in Either Organic Solvent or Water

Landstrom, E. B.; Handa, S.; Aue, D. H.; Gallou, F.; Lipshutz, B. H.

Green Chem. 20, 3436

Article
2018

B-Alkyl sp3-sp2 Suzuki-Miyaura Couplings Under Mild Aqueous Micellar Conditions

Lee, N. R.; Linstadt, R. T. H.; Gloisten, D. J.; Gallou, F.;  Lipshutz, B. H.

Org. Lett. 20, 2902 Article
2018

Structure of Nanoparticles Derived from Designer Surfactant TPGS-750-M in Water, as Used in Organic Synthesis

Andersson, M.; Gallou, F.; Klumphu, P.; Takale, B.,  Lipshutz, B. H.

Chem. Eur. J. 24, 6778

Article
2018

PQS-enabled Visible-Light Iridium Photoredox Catalysis in Water at Room Temperature

Bu, M-j.; Cai, C.; Gallou, F.; Lipshutz, B. H.

Green Chem. 20, 1233 Article
2018

Sustainable HandaPhos-ppm Palladium Technology for Copper-Free Sonogashira Couplings in Water under Mild Conditions

Handa, S.; Smith, J. D.; Zhang, Y.; Takale, B. S.; Gallou, F.; Lipshutz, B. H.

Org. Lett. 20, 542 Article
2018

Synergistic Effects in Fe Nanoparticles doped with ppm levels of (Pd + Ni). A New Catalyst for Sustainable Nitro Group Reductions

Pang, H.; Gallou, F.; Sohn, H.; Camacho-Bunquin, J.; Delferro, M.; Lipshutz, B. H.

Green Chem. 20, 130 Article
2017

Carbonyl Iron Powder: A Reagent for Nitro Group Reduction Under Aqueous Micellar Catalysis Conditions

Lee, N. R.; Bikovtseva, A. A.; Cortes-Clerget, M.; Gallou, F.; Lipshutz, B. H.

Org. Lett. 19, 6518 Article
2017

A Micellar Catalysis Strategy for Suzuki-Miyaura Cross-Coupling of 2-Pyridyl MIDA Boronates: No Copper, in Water, Very Mild Conditions

Isley, N. A.; Wang, Y.; Gallou, F.; Handa, S.; Aue, D. H.; Lipshutz, B. H.

ASC Catal., 7, 8331 Article
2017

Tandem deprotection/coupling for peptide synthesis in water at room temperature

Cortes-Clerget, M.; Berthon, J-Y.; Krolikewicz-Renimel, I.; Chaisemartin, L.; Lipshutz, B. H.

Green Chem., 19, 4263 Article
2017

Micellar catalysis-enabled sustainable ppm Au-catalyzed reactions in water at room temperature

Klumphu, P.; Desfeux, C.; Zhang, Y.; Handa, S.; Gallou, F.; Lipshutz, B. H.

Chem. Sci., 8, 6354

Article
2017

Fe/ppm Cu nanoparticles as a recyclable catalyst for click reactions in water at room temperature

Adenot, A.; Landstrom, E. B.; Gallou, F.; Lipshutz, B. H.

Green Chem., 19, 2506 Article
2017

Sustainable and Scalable Fe/ppm Pd Nanoparticle Nitro Group Reductions in Water at Room Temperature

Gabriel, C. M.; Parmentier, M.; Riegert, C.; Lanz, M.; Handa, S.; Lipshutz, B. H.; Gallou, F.

OPRD, 21, 247 Article
2017

Control of Chemo-, Regio-, and Enantioselectivity in Copper Hydride Reductions of Morita-Baylis-Hillman Adducts

Linstadt, R. T. H; Peterson, C. A.; Jette, C. I.; Boskovic, Z. V.; Lipshutz, B. H.

Org. Lett., 19, 328 Article
2017

From Milligrams to Grams. SNAr Reactions in Aqueous Nanomicelles: No Dipolar Aprotic Solvents Needed

Lee, N. R.; Gallou, F.; Lipshutz, B. H.

OPRD, 21, 218 Article
2017

Effects of Co-solvents on Reactions Run under Micellar Catalysis Conditions

Gabriel, C. M.; Lee, N. R.; Bigorne, F.; Klumphu, P.; Parmentier, M.; Gallou, F.; Lipshutz, B. H.

Org. Lett., 19, 194 Article
2017

Synthesis of Functionalized [3], [4], [5] and [6]Dendralenes through Palladium-Catalyzed Cross-Couplings of Substituted Allenoates

Lippincott, D. J.; Linstadt, R. T. H.; Maser, M. R.; Lipshutz, B. H.
 

Angew. Chem., Int. Ed. 56, 847.

Angew. Chem. 129, 865.

Article
2016

Synergistic and Selective Copper/ppm Pd-Catalyzed Suzuki-Miyaura Couplings: In Water, Mild Conditions, with Recycling

Handa, S.; Smith, J. D.; Hageman, M. S.; Gonzalez, M.; Lipshutz, B. H.
 
ACS Catal., 6, 8179 Article
2016

Safe and Selective Nitro Group Reductions Catalyzed by Sustainable and Recyclable Fe/ppm Pd Nanoparticles in Water at Room Temperature

Feng, J.; Handa, S.; Gallou, F.; Lipshutz, B. H.
 
Angew. Chem. Int. Ed., 55, 8979 Article
2016

Cationic Pd(II)-catalyzed C–H activation/cross-coupling reactions at room temperature: synthetic and mechanistic studies

Nishikata, T.; Abela, A. R.; Huang, S.; Lipshutz, B. H.
 
Beilstein J. Org. Chem, 12, 1040 Article
2016

HandaPhos: A General Ligand Enabling Sustainable ppm Levels of Palladium-catalyzed Cross-Couplings in Water at Room Temperature

Handa, S.; Andersson, M. P.; Gallou, F.; Reilly, J.; Lipshutz, B. H.
 
Angew. Chem. Int. Ed., 55, 4914 Article
2015

High-performance mussel-inspired adhesives of reduced complexity

Ahn, B. K.; Das, S.; Linstadt, R. T. H. ;Kaufman, Y.; Martinez-Rodriguez, N. R; Mirshafian, R.; Kesselman, R.; Talmon, Y.; Lipshutz, B. H.; Israelachvili, J. N.; Waite, J. H.
 
Nat. Comm., 6, 8663 Article
2015

Sustainable Fe-ppm Pd nanoparticle catalysis of Suzuki-Miyaura cross-couplings in water

Handa, S.; Wang, Ye; Gallou, F.; Lipshutz, B. H.

Science, 349, 1087

Abstract

Article

2015

Nucleophilic Aromatic Substitution Reactions in Water Enabled by Micellar Catalysis

Isley, N. A.; Linstadt, R. T. H.; Kelly, S. M.; Gallou, F.; Lipshutz, B. H.

Org. Lett., 17, 4734

(Outstanding Publication of the Year)

Article

Review

2015

Nanonickel-Catalyzed Suzuki–Miyaura Cross-Couplings in Water

Handa, S.; Slack, E. D.; Lipshutz, B. H.

Angew. Chem. Int. Ed., 54 ,11994 Article
2015

Kumada–Grignard-type biaryl couplings on water

Bhattacharjya, A.; Klumphu, P.; Lipshutz B. H.

Nat. Comm., 6, 7401 Article
2015

Amide and Peptide Bond Formation in Water at Room Temperature

Gabriel, C. M.; Keener, M.; Gallou, F.; Lipshutz, B. H.

Org. Lett., 17, 3968 Article
2015

Reductions of Aryl Bromides in Water at Room Temperature

Fennewald, J. C.; Landstrom, E. B.; Lipshutz, B. H.

Tet. Lett., 56, 3608 Article
2015

Ligand-?Free, Palladium-?Catalyzed Dihydrogen Generation from TMDS: Dehalogenation of Aryl Halides on Water

Bhattacharjya, A.; Klumphu, P.; Lipshutz, B. H.

Org. Lett., 17, 1122 Article
2015

Dehalogenation of Functionalized Alkyl Halides in Water at Room Temperature

N. A. Isley, M. S. Hageman, B. H. Lipshutz

Green Chem., 2015, 17, 893

Article
2014

Asymmetric Gold-Catalyzed Lactonizations in Water at Room Temperature

S. Handa, D. J. Lippincott, D. H. Aue, B. H. Lipshutz

Angew. Chem., Int. Ed., 53, 10658 Article
2014

A Palladium Nanoparticle-Nanomicelle Combination for the Stereoselective Semihydrogenation of Alkynes in Water at Room Temperature

E. D. Slack, C. M. Gabriel, B. H. Lipshutz

Angew. Chem., Int. Ed., 53, 14051 Article
2014

Stereoretentive Pd-Catalyzed Kumada-Corriu Couplings of Alkenyl Halides at Room Temperature 

A. Krasovskiy; S. Haley, K. Voidtritter, B. H. Lipshutz

Org. Lett. 16, 4066 Article
2014

Copper-catalyzed Hydrophosphinations in Water at Room Temperature

N. A. Isley, R. T. Linstadt, E. Slack, B. H. Lipshutz

Dalton Trans., 43, 13196 Article
2014

Aerobic Oxidation in nanomicelles of Aryl Alkynes, in Water at Room Temperature

S. Handa, J. C. Fennewald, B. H. Lipshutz

Angew. Chem., Int. Ed., 53, 3432  Article
2014

Stereoselective Silylcuprations of Conjugated Alkynes in Water at Room Temperature

R. T. H. Linstadt, C. A. Peterson, D. J. Lippincott, C. I. Jette, B. H. Lipshutz

Angew. Chem. Int. Ed., 53, 4159 Article
2014

Selective oxidations of activated alcohols in water at room temperature

B. H. Lipshutz, M. Hageman, J. C. Fennewald, R. Linstadt, E. Slack, K. Voigtritter

Chem. Comm. 50, 11378

Article

2014

Leveraging the Micellar Effect:  Gold-Catalyzed Dehydrative Cyclizations…in Water at Room Temperature

S. R. K. Minkler, N. A. Isley, D. J. Lippincott, N. Krause, B. H. Lipshutz

Org. Lett., 16, 724 Article
2014

Copper-catalyzed trifluoromethylation of N-arylacrylamides “on water” at Room Temperature 

F. Yang, P. Klumphu, Y-M. Liang, B. H. Lipshutz

Chem. Comm., 50, 936 Article
2014

“Nok”: A Phytosterol-Based Amphiphile Enabling Transition Metal-Catalyzed Couplings in Water at Room Temperature 

P. Klumphu, B. H. Lipshutz

J. Org. Chem., 79, 888         Article
2014

Chemoselective Reductions of Nitroaromatics in Water at Room Temperature

S. M. Kelly, B. H. Lipshutz

Organic Lett., 16, 98 Article
2014

Installation of Protected Ammonia Equivalents onto Aromatic and Heteroaromatic Rings in Water Enabled by Micellar Catalysis

N. A. Isley, S. Dobarco, B. H. Lipshutz

Green Chem., 16, 1480 Article
2014

Trifluoromethylations of Heterocycles in Water at Room Temperature

J. C. Fennewald, B. H. Lipshutz

Green Chem., 16, 1097 Article
2013

Transforming Suzuki-Miyaura cross-couplings of MIDA boronates into a green technology: No Organic Solvents

N. A. Isley, F. Gallou, B. H. Lipshutz

J. Am. Chem. Soc., 135, 17707 Article
2013

“Click” and Olefin Metathesis Chemistry in Water at Room Temperature Enabled by Biodegradable Micelles

B. H. Lipshutz, Z. Boskovic, C. S. Crowe, V. K. Davis, H. C. Whittemore, D. A. Vosburg, and A. G. Wenzel

 J. Chem. Ed.,  90, 1514          Article
2013

Stille Couplings in Water at Room Temperature

G-P. Lu, C. Cai, B. H. Lipshutz

Green Chem., 15, 105 Article
2012
C–C Bond Formation via Copper-Catalyzed Conjugate Addition Reactions to Enones in Water at Room Temperature
 
B. H. Lipshutz, S. Huang, W. W. Y. Leong, G. Zhong, N. A. Isley
J. Am. Chem. Soc., 134, 19985 Article
2012

Ligand Effects on the Stereochemistry of Stille Couplings, as Manifested in Reactions of Z-Alkenyl Halides

G-P. Lu, K. R. Voigtritter, C. Cai, B. H. Lipshutz

Chem. Comm., 48, 8661 Article
2012

Ligand Effects on the Stereochemistry of Suzuki-Miyaura Couplings

G-P. Lu, K. R. Voigtritter, C. Cai, B. H. Lipshutz

J. Org. Chem. 77, 3700 Article
2012

Rh-Catalyzed Asymmetric 1,4-Addition Reactions in Water at Room Temperature with In-Flask Catalyst Recycling

B. H. Lipshutz, N. Isley, R. Moser, H. Leuser, B. R. Taft

Adv. Syn. Catal. 354, 3175 Article
2012

Modified Routes to the “Designer” Surfactant PQS

R. Moser, S. Ghorai, B. H. Lipshutz

J. Org. Chem. 77, 3143 Article
2012

Organocatalysis in Water at Room Temperature with In-Flask Catalyst Recycling

B. H. Lipshutz, S. Ghorai

Organic Lett. 14, 422 Article
2012

Regioselective reductions of b,b-disubstituted enones catalyzed by nonracemically ligated copper hydride

K. Voigtritter, N. Isley, R. Moser, D. H. Aue, B. H. Lipshutz

Tetrahedron Symposiun-in-Print (invited), 68, 3410 Article
2011

Gold Catalysis in Micellar Systems 

S. R. K. Minkler, B. H. Lipshutz, N. Krause

Angew. Chem., Int. Ed. 50, 7820 Article
2011

Organozinc Chemistry Under Micellar Catalysis Conditions.  Cross-Couplings Between Alkyl and Aryl Bromides in Water at Room Temperature

C. Duplais, A. Krasovskiy, and B. H. Lipshutz

Organometallics (invited), 30, 6090. Article
2011

Manipulating Micellar Environments for Enhancing Transition Metal-Catalyzed Cross-Couplings in Water at Room Temperature

B. H. Lipshutz, S. Ghorai, W. W. Y. Leong, R. Moser, B. R. Taft

J. Org. Chem. 76, 5061. Article
2011

Stereoselective Reactions Between Unbiased Alkenyl & Alkylzinc Halides:  Negishi-Plus Couplings 

A. Krasovskiy and B. H. Lipshutz

Organic Lett., 13, 3822. Article
2011

Ligand Effects in Negishi Cross-Couplings of Z-Alkenyl Halides

A. Krasovskiy, C. Duplais, B. H. Lipshutz

Org. Lett. 13, 3818. Article
2011

Enhanced Olefin Cross Metathesis Reactions:  The Copper Iodide Effect

K. Voigtritter, S. Ghorai, B. H. Lipshutz

J. Org. Chem. 76, 4697. Article
2011

TPGS-750-M:  A Second-Generation Amphiphile for Metal-Catalyzed Cross-Couplings in Watrer at Room Temperature

B. H. Lipshutz, S. Ghorai, A. R. Abela, R. Moser, T. Nishikata, C.Duplais, A. Krasovskiy

J. Org. Chem. 76, 4379. Article
2011

“On water” sp3-sp2- cross-couplings between benzylic and alkenyl halides

V. Krasovskaya, A. Krasovskiy, A. Bhattacharjya, B. H. Lipshutz

Chem. Comm. 47, 5717. Article
2011

Cross-couplings of alkyl halides with heteroaromatic halides, in water at room temperature

A. Krasovskiy, I. Thome, J. Graff, V. Krasovskaya, P. Konopelski, C. Duplais, B. H. Lipshutz

Tetrahedron Lett. 52, 2203. Article
2010

Stereoselective Negishi-like Couplings of Alkenyl Halides with Alkyl Halides in Water at Room Temperature

A. Krasovskiy, C. Duplais, B. H. Lipshutz

Org. Lett. 12, 4742. Article
2010

Miyaura Borylations of Aryl Bromides in Water @ RT

B. H. Lipshutz, R. Moser, K. R. Voigtritter

Isr. J. Chem. (invited) 50, 691. Article
2010

Asymmetric CuH-Catalyzed 1,4-Reductions in Water @ RT

S. Huang, K. Voigtritter, J. B. Unger, B. H. Lipshutz

Synlett Cluster on Green Chemistry (invited) 2041 Article
2010

Enantioselective Total Synthesis of Korupensamine B

S. Huang, T. Petersen, B. H. Lipshutz

J. Am. Chem. Soc. 132, 14021. Article
2010

CuH-Catalyzed Enantioselective 1,2-Reductions of a,b-Unsaturated Ketones

R. Moser, Z. V. Boskovic, C. S. Crowe, B. H. Lipshutz

J. Am. Chem. Soc. 132, 7852. Article
2010

Cationic Pd(II) Catalyzed Fujiwara-Moritani Reactions at Room Temperature in Water

T. Nishikata, B. H. Lipshutz

Org. Lett. 12, 1972. Article
2010

Cationic Pd(II) Catalysis:  C-H Activation/Suzuki-Miyaura Couplings at Room Temperature

T. Nishikata, A. R. Abela, S. Huang, B. H. Lipshutz

J. Am. Chem. Soc. 132, 4978. Article
2010

Cross-Couplings Between Benzylic and Aryl Halides “On Water.”  Synthesis of Diarylmethanes

C. Duplais, A. Krasovskiy, A. Wattenberg, B. H. Lipshutz

Chem. Comm. 46, 562 Article
2010

Room Temperature C-H Activation & Cross-Coupling of Aryl Ureas in Water

T. Nishikata, A. R. Abela, B. H.  Lipshutz

Angew. Chem. Int. Ed. 49, 781 Article
2010

UC Pd: A new form of Pd/C for Sonogashira couplings

C. Duplais, A. J. Forman, B. A. Baker, B. H. Lipshutz

Chem. Eur. J. 16, 3366 Article
2010

PQS-2.  Ring-closing and cross-metathesis reactions on lipophilic substrates: in water only at room temperature, with in-flask catalyst recycling

B. H. Lipshutz, S. Ghorai

Tetrahedron, 66,1057 (Symposium-in-Print; green chemistry; co-Editor) Article
2010

Pd-Catalyzed Synthesis of Allylic Silanes from Allylic Ethers

R. Moser, T. Nishikata, B. H. Lipshutz

Org. Lett. 12, 28 Article
2009

Synthesis and Characterization of Isomeric Vinyl-1,2,3-triazole Materials by Azide-Alkyne Click Chemistry

Nulwala, H.; Takizawa, K; Odukale, A.; Khan, A.; Thibault, R. J.; Taft, B. R.; Lipshutz, B. H.; Hawker, C. J.

Macromolecules 42, 6068. Article
2009

Cu/C-Catalyzed, Tandem 1-Pot Diazo Transfer-Click Reactions

C-T. Lee, S. Huang, and B. H. Lipshutz

Adv. Syn. Catal. 353, 3139 Article
2009

Asymmetric Conjugate Reductions of Coumarins.  A New Route to Tolterodine and Related Coumarin Derivatives

B. D. Gallagher, B. R. Taft, B. H. Lipshutz

Org. Lett. 11, 5374. Article
2009

Aminations of Allylic Phenyl Ethers via Micellar Catalysis at Room Temperature in Water

T. Nishikata, B. H. Lipshutz

Chem. Comm. 6472 Article
2009

Zinc-Mediated, Pd-Catalyzed Cross-Couplings in Water at Room Temperature without Prior Formation of Organozinc Reagents

A. Krasovskiy, C. Duplais, B. H. Lipshutz

J. Am. Chem. Soc. 131, 15592 Article
2009

An (NHC)CuH-Catalyzed Entry to Allenes via Propargylic Carbonate SN2’ Reductions

C. Deutsch, B. H. Lipshutz, N. Krause

Org. Lett. 11, 5010. Article
2009

Allylic Ethers as Educts for Suzuki-Miyaura Couplings in Water at Room Temperature

T. Nishikata, B. H. Lipshutz

J. Am. Chem. Soc. 131, 12103 Article
2009

Aminations of Aryl Bromides in Water at Room Temperature

B H. Lipshutz, D. W. Chung, B. Rich

Adv. Syn. Catal. 351, 1717 Article
2009

Amination of Allylic Alcohols in Water at Room Temperature

T. Nishikata, B. H. Lipshutz

Org. Lett. 11, 2377 Article
2009

PQS:  A Newly Designed Platform for Micellar Catalysis. RCM Reactions in Water with Catalyst Recycling

B. H. Lipshutz, S. Ghorai

Org. Lett. 11, 705 Article
2009

A Convenient Preparation of Di-p-Chlorobenzyl Azodicarboxylate (DCAD) for Mitsunobu Couplings

B. H. Lipshutz, B. R. Taft, E. C. Swift

Synthesis (PSP) 332 Article
2009

Deprotection of Homoallyl (hAllyl) Derivatives of Phenols, Alcohols, Acids, and Amines”

B. H. Lipshutz, S. Ghorai

J. Org. Chem. 74, 2854 Article
2009

“Carboalumination/Ni-catalyzed couplings. A short synthesis of verticipyrone

B. H. Lipshutz, B. Amorelli 

Tetrahedron Lett. 50, 2144.  Article
2009

Total Synthesis of Piericidin A1.  Application of a Modified Negishi Carboalumination-Nickel-Catalyzed Cross-Coupling”

B. H. Lipshutz, B. Amorelli

J. Am. Chem. Soc. 131, 1396 Article
2008

Activated Alkenylboronates from Acetylenic Esters via CuH-Catalyzed 1,2-Addition/Transmetalation

B. H. Lipshutz, Z. V. Boskovic, D. H. Aue

Angew. Chem. Int. Ed. 47, 10183 Article
2008

Micellar Catalysis of Suzuki-Miyaura Cross-Couplings with Heteroaromatics in Water

B. H. Lipshutz, A. R. Abela

Org. Lett. 10, 5329 Article
2008

Copper + Nickel-in-Charcoal (Cu-Ni/C):  A Bimetallic, Heterogeneous Catalyst for Cross-Couplings

B. H. Lipshutz, D. M. Nihan, E. Vinogradova, B. R. Taft, Z. V. Boskovic

Org. Lett. 10, 4279 Article
2008

Nonracemic Diarylmethanols From CuH-Catalyzed Hydrosilylation of Diaryl Ketones

C-T. Lee, B. H. Lipshutz

Org. Lett. 10, 4187 Article
2008

Sonogashira Couplings of Aryl Bromides:  Room Temperature, Water Only, No Copper

B. H. Lipshutz, D. W. Chung, B. Rich

Org. Lett. 10, 3793 Article
2008

Tandem olefin metathesis-elimination reactions.  A new route to doubly unsaturated carbonyl derivatives

B. H. Lipshutz, S. Ghorai, Z. V. Boskovic

Tetrahedron 64, 6949 (invited) Article
2008

Ring-closing Metathesis at Room Temperature within Nanometer Micelles Using Water as the Only Solvent

B. H. Lipshutz, S. Ghorai, G. Aguinaldo

Adv. Syn. Catal. 350, 953 Article
2008

C-C Bond Formation Catalyzed Heterogeneously by Nickel-on-Graphite (Ni/Cg)

B. H. Lipshutz, T. Butler, E. Swift

Org. Lett. 10, 697 Article
2008

Room Temperature Suzuki-Miyaura Couplings in Water Facilitated by Nonionic Amphiphiles

B. H. Lipshutz, T. B. Petersen, A. Abela

Org. Lett. 10, 1333 Article
2008

Heck Couplings at Room Temperature in Nanometer Aqueous Micelles

B. H. Lipshutz, B. R. Taft

Org. Lett, 10, 1329 Article
2008

Olefin Cross-Metathesis Reactions at Room Temperature Using the Nonionic Amphiphile “PTS”; Just Add Water

B. H. Lipshutz, G. T. Aguinaldo, S. Ghorai, K. Voigtritter

Org. Lett. 10, 1325 Article
2008

(BDP)CuH: A “Hot” Stryker’s Reagent for Use in Achiral Conjugate Reductions

B. A. Baker, Z. V. Boskovic, B. H. Lipshutz

Org. Lett. 10, 289 Article