The Lipshutz group is focused on research in several areas of synthetic organic chemistry. These include a heavy emphasis on green chemistry, where the goal is to devise new technologies aimed at getting organic solvents out of organic reactions.

More traditional methodologies are also under development, in many cases involving transition metal-catalyzed processes. Total syntheses are ongoing as well, with an accent on axially chiral, naturally occurring and physiologically active biaryls.

We invite you to explore our web site to learn more about our programs.

Recent News

Read our "Behind the paper" post on the Nature Research Community blog and learn more about our recently published article "Bridging the gap between transition metal and bio-catalysis via aqueous micellar catalysis". 

  • Takeda, Cambridge, MA, May 30, 2019

Recent Publications

 

"Bridging the gap between transition metal- and bio-catalysis via aqueous micellar catalysis"

Cortes-Clerget, M.; Akporji, N.; Zhou, J.; Gao, F.; Guo, P.; Parmentier, M.; Gallou, F.; Berthon, J-Y.; Lipshutz, B. H. Nat. Comm. 2019.

"Synthetic chemistry in water: applications to peptide synthesis and nitro-group reductions"

Cortes-Clerget, M.; Lee, N. R.; Lipshutz, B. H. Nat. Protoc. 2019, 14, 1108.

"Coolade. A Low-Foaming Surfactant for Organic Synthesis in Water"

Lee, N. R.; Cortes-Clerget, M.; Wood, A.;  Lippincott, D. J.; Pang, H.; Moghadam, F.; Gallou, F.; Lipshutz, B.H. ChemSusChem, Accepted.

"Sonogashira Couplings Catalyzed by Fe Nanoparticles Containing ppm Levels of Reusable Pd, under Mild Aqueous Micellar Conditions"

Handa, S.; Bo, J.; Bora, P. P.; Wang, Y.; Zhang, X.; Gallou, F.; Reilly, J.; Lipshutz, B. H. ACS Catal. 2019, 9, 2423.

"ppm Pd-Catalyzed, Cu-free Sonogashira couplings in water using commercially available catalyst precursors"

Bo, J.; Reilly, J.; Gallou, F.; Lipshutz, B. H. Chem. Sci. 2019, 10, 3480.

More Publications