The Lipshutz group is focused on research associated with synthetic organic chemistry with a heavy emphasis on green chemistry. The goals include development of new technologies aimed at (1) getting organic solvents out of organic reactions, using minimum amounts of recyclable water as the reaction medium; (2) reducing the need for endangered metal catalysts, especially Pd, to ppm levels, and (3) enabling reactions to be run under very mild conditions (i.e., between rt and 45 °C) thereby minimizing by-product formation and maximizing overall efficiencies; (4) merging chemo-catalysis with bio-catalysis, where both types of reactions are utilized in the common medium:  water.

We invite you to explore our web site to learn more about our programs in environmentally responsible synthetic chemistry.

Recent News

With great sorrow we bid goodbye to Alex B. Wood.

We are excited to welcome a new graduate student to the group, Erfan Oftadeh. Welcome aboard!...

Recent Publications

"An Environmentally Responsible and Cost-effective Synthesis of the Antimalarial Drug Pyronaridine"

Kincaid, J. R. A.; Kavthe, R., D.; Caravez, J. C.; Takale, B. S.; Thakore, R. R.; and Lipshutz, B. H. Org. Lett. 2022, accepted

"An Environmentally Responsible Synthesis of the Antitumor Agent Lapatinib (Tykerb)"

Yu, J.; Iyer, K. S.; Lipshutz, B. H. Green Chem. 2022, Advanced Article 

"Dehydration of primary amides to nitriles in water. Late-stage functionalization and 1-pot multistep chemoenzymatic processes under micellar catalysis conditions"

Wood, A. B.; Kincaid, J. R. A.; Lipshutz, B. H. Green Chem. 2022, 24, 2853

"Lipase-catalyzed esterification in water enabled by nanomicelles. Applications to 1-pot multi-step sequences"

Singhania, V.; Cortes-Clerget, M.;Dussart-Gautheret, J.; Akkachairin, B.; Yu, J.; Akporji, N; Gallou, G; Lipshutz, B. H. Chem. Sci. 2022, 13, 1440



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