The Lipshutz group is focused on research associated with synthetic organic chemistry with a heavy emphasis on green chemistry. The goals include development of new technologies aimed at (1) getting organic solvents out of organic reactions, using minimum amounts of recyclable water as the reaction medium; (2) reducing the need for endangered metal catalysts, especially Pd, to ppm levels, and (3) enabling reactions to be run under very mild conditions (i.e., between rt and 45 °C) thereby minimizing by-product formation and maximizing overall efficiencies; (4) merging chemo-catalysis with bio-catalysis, where both types of reactions are utilized in the common medium:  water.

We invite you to explore our web site to learn more about our programs in environmentally responsible synthetic chemistry.

Recent News

We are pleased to welcome our new graduate students, Rohan, Maddie, Juan, Karthik, and Katie! ...

Micelles work like nano-reactors to help chemistry become more natural.

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Recent Publications

 

"Late-stage Pd-catalyzed cyanations of aryl/heteroaryl halides in aqueous micellar media"

Thakore, R. R., Takale, B. S., Singhania, V., Gallou, F., Lipshutz, B. H. ChemCatChem. 2021, 13, 212

"Mild and robust Stille reactions in water using ppm levels of a
new triphenylphosphine-based palladacycle"

Takale, B. S., Thakore, R. R., Casotti, G., Li, X., Gallou, F., Lipshutz, B. H. Angew. Chem. Int. Ed. 2021, 60, 2

"Safe, Scalable, Inexpensive, and Mild Nickel‐Catalyzed Migita‐like C–S Cross‐Couplings in Recyclable Water"

Yu, T., Pang, H., Cao, Y., Gallou, F., Lipshutz, B. H. Angew. Chem. Int.  Ed. 2020, 59, 2

"Environmentally responsible, safe, and chemoselective catalytic hydrogenation of olefins: ppm level Pd catalysis in recyclable water at room temperature"

Takale, B. S., Thakore, R. R., Gao, E. S., Gallou, F. Lipshutz, B. H. 2020, Green Chem. 22, 6055Sustainable routes to amines in recyclable water using ppm Pd catalysis"

 

 

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