The Lipshutz group is focused on research associated with synthetic organic chemistry with a heavy emphasis on green chemistry. The goals include development of new technologies aimed at (1) getting organic solvents out of organic reactions, using minimum amounts of recyclable water as the reaction medium; (2) reducing the need for endangered metal catalysts, especially Pd, to ppm levels, and (3) enabling reactions to be run under very mild conditions (i.e., between rt and 45 °C) thereby minimizing by-product formation and maximizing overall efficiencies; (4) merging chemo-catalysis with bio-catalysis, where both types of reactions are utilized in the common medium:  water.

We invite you to explore our web site to learn more about our programs in environmentally responsible synthetic chemistry.

Recent Publications

SNAr Reactions Using Continuous Plug Flow...in Aqueous Biphasic Media
 
Wong, M. J.‡; Freiberg, K. M.‡; Reynafarje Jones, T.; Dismuke Rodriguez, K. B.; Wood, A. B.; and Lipshutz B. H. ACS Sustainable Chem. Eng. 2024, 12, 52, 18725–18734

 

Reactions of in situ-generated difluorocarbene (:CF2) with aromatic/heteroaromatic alcohols, thiols, olefins, and alkynes under environmentally responsible conditions
 
Oftadeh, E.; Wong, M. J.; Yu, J.; Li, X.; Cao, Y.; and Lipshutz, B. H. J. Org. Chem. 2024, 89, 23, 17331–17337
 

Following Nature’s Lead. Designing a Very Simple yet Effective Ligand System Applicable to Pd-Catalyzed Cross Couplings…in Water

Oftadeh, E.; Baumann, M.; Ortiz, M.; Mamo, K.; Boeira, E.; Nguyen, S.; Aue, D. H.; and Lipshutz B. H.

 

Environmentally friendly Miyaura Borylations allowing for green, 1-pot borylation/Suzuki-Miyaura couplings

Nelson, C. B.; L'Heureux, S. J.; Wong, M. J.; Kuhn, S. L.; Ghigletti, E.; and Lipshutz B. H. Green Chem., 2024, 26, 10115

 

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