The Lipshutz group is focused on research associated with synthetic organic chemistry with a heavy emphasis on green chemistry. The goals include development of new technologies aimed at (1) getting organic solvents out of organic reactions, using minimum amounts of recyclable water as the reaction medium; (2) reducing the need for endangered metal catalysts, especially Pd, to ppm levels, and (3) enabling reactions to be run under very mild conditions (i.e., between rt and 45 °C) thereby minimizing by-product formation and maximizing overall efficiencies; (4) merging chemo-catalysis with bio-catalysis, where both types of reactions are utilized in the common medium:  water.

We invite you to explore our web site to learn more about our programs in environmentally responsible synthetic chemistry.

Recent Publications

Synthesis of S,S-di(pyridin-2-yl)carbonodithioate (DPDTC) and its use in the reduction of a carboxylic acid to the corresponding alcohol, employing a green reaction medium
 
Iyer, K. S.; Yirak, J. R.; Muchalski, H.; and Lipshutz, B. H. Org. Syn. 2024, 101, 274-294

 

Rapid aminations of functionalized aryl fluorosulfates in water

Iyer, K. S.; Dismuke Rodriguez, K. B.‡; Lammert, R. M.‡; Yirak, J. R.; Saunders, J. M.; Kavthe, R. D.; Aue, D. H.; and Lipshutz, B. H. Angew. Chem. Int. Ed. 2024, e202411295
 
 
 
Dehydration in Water. Solid-Supported Lipases as Green Catalysts for Esterification

Thomas, R. M.; Lopez-Lemus, M. S.; Ganesh, K.; Obbard, D. B.; Sivashanmugam, K.; Sambasivam, G.; Yang, Y.; and Lipshutz, B. H. Green Chem. 2024 10.1039/d4gc02904f

 

Preparation of a key intermediate en route to the anti-HIV drug lenacapavir
 
Caravez, J. C.; Hu, Y.; Oftadeh, E.; Mamo, K. T.; and Lipshutz, B. H. J. Org. Chem. 2024, 89, 3996-4000

 

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